Roach's calf strain sidelines him for at least four games, forcing Denver to lean on Jordan Jackson and Eyioma Uwazurike for early-season interior disruption. The Broncos promoted Sam Ehlinger to the 53-man roster as an emergency No. 3 quarterback, ensuring depth on game days without counting toward the active roster. Adam Prentice and Levelle Bailey were elevated from the practice squad to bolster fullback and linebacker depth ahead of Week 1 against Tennessee, while SF's injury to Dre Greenlaw looms as a defensive angle for fantasy managers.

Denver's early-season path leans on improved DL rotation, with Roach out and Jackson/Uwazurike stepping up. Ehlinger’s return adds a mobile quarterback option in emergency scenarios, and Prentice Bailey provides insurance at crucial HB/LB spots. Week 1 becomes a test of depth, roster construction, and adaptive game plans as the Broncos navigate Roach's absence and SF's defensive matchup.