Denver’s heartbreak on the road to Indianapolis came with a brain-fade finish: a 29-28 loss driven by late penalties, missed opportunities and a 60-yard game-winner that capped a sequence of missteps. Dobbins’ delay of game, a wayward punt of momentum, a doinked 42-yarder by Wil Lutz, and a controversial Uwazurike/Tillman call highlighted a night of cognitive disconnects for Denver.

With the Colts stealing momentum late, questions loom about Sean Payton’s clock management and Shane Steichen’s finish drive. For fantasy managers, the ending reshapes expectations around Broncos targets, kickers and defense, and it plants early-week narratives ahead of matchups with the Chargers, Bengals and Eagles.

In all, the ending becomes a cautionary tale for late-season optimism and a reminder that execution in crunch time can redefine a season’s arc and fantasy value alike.

Arizona moved to 2-0 in the 2025 season by molding necessity into advantage. A quick-struck 10-0 lead sprang from a Bryce Young fumble forced by Josh Sweat, then a Zaven Collins scoop-and-score capped the turnover spree that set the tone early.

The second-quarter surge blossomed with back-to-back red-zone threats and a late-half dagger: Greg Dortch’s 29-yard punt return set up a Murray-to-Wilson TD with 47 seconds left before the break, followed by a 71-yard march to James Conner’s score to start the third. The defense buckled late, but Calais Campbell sealed the win on a fourth-and-15 tackle as Arizona weathered Carolina’s rally and improved to 2-0 heading to San Francisco.

Two turnovers, decisive drives, and a closing stand. The Cardinals leaned on opportunism and timely stops to steady a young, imperfect offensive day, showing enough to keep bettors optimistic for a tough schedule ahead against the 49ers.