Denver inventories an ACL setback for Nick Gargiulo after a preseason collision, sidelining a seventh-round rookie who had been pushing for a swing guard/center role. Sean Payton confirmed the season-ending injury to Gargiulo, compounding Denver’s alignment questions along the interior line. Gargiulo’s absence tightens the Broncos’ path to roster decisions and creates immediate depth concerns as cuts loom.

Meanwhile, the injury report also notes others not practicing, with Mathis listed as undisclosed but deemed fine by Payton. On the brighter side, Bonitto, Greenlaw, Perry, and Pickett returned to practice. Adkins’ ankle loss signals a potential waiver-wire search for a blocking tight end/fullback, and the Broncos may lean on depth pieces or a short-term add as they finalize roster plans.