Denver aims to flip a historical rough start by opening 2-0, leaning on a veteran defense and a run-heavy attack as Payton rebuilds the offense around Bo Nix. Indy arrives with a refreshed vibe and Daniel Jones orchestrating seven straight scoring drives in Week 1, setting up a clash of Denver’s defensive prowess against Indy’s high-functioning new-look unit.

For fantasy managers, Nix’s turnover risk vs. Indy’s secondary and Jones’ quick-strike rhythm against Denver’s defense are the key storyline drivers. Monitor how the Broncos protect the ball and control pace, while Indy tests Denver’s back-end and pressure at Lucas Oil. Week 2 fantasy pivots hinge on game-script and run/throw balance.

Calvin Ridley enters Week 2 as Tennessee's clear WR1, but his upside is capped by Cam Ward's rookie transition and a Rams defense that was stingy with WRs last week. After a rough opener against Denver, Ridley's floor remains solid in PPR as a mid-range WR3, with limited big-play upside in standard formats. In shallow leagues or if the Titans lean on Week 2 volume, Ridley remains a viable flex option.