Purdue has 14 alumni on NFL rosters for the 2025 season, led by George Karlaftis in Kansas City. Aidan O’Connell and Raheem Mostert link up for the Raiders, while Tyrone Tracy Jr. and Marcus Mbow may pair again with the Giants. Charlie Jones, Payne Durham, Derrick Barnes, Sanoussi Kane, Rondale Moore, David Bell, Cory Trice Jr., Jalen Graham, and Reese Taylor are scattered across the league, offering depth and late-round fantasy/IDP upside across Bengals, Buccaneers, Lions, Ravens, Vikings, Browns, Steelers, 49ers, Giants, and Broncos.

The Purdue pipeline continues to influence dynasty and streamer decisions, with injury notes, camp chatter, and depth-chart shifts shaping how owners value Purdue-affiliated players in the weeks ahead. Stakeholders should monitor IR statuses for O’Connell, backfield splits in Vegas, and Giants’ backfield competition as the season unfolds.