Week 2 DFS spotlight centers on five RB matchups: Gibbs vs Bears, McCaffrey vs Saints, Conner vs Panthers, Hall vs Bills, Williams vs Cowboys. The focus is on game-script independent backs who can reach 15-20 touches regardless, a rarity in today’s NFL.

The Lions look to rebound at home while Chicago’s run defense isn’t as stout as last year. Arizona and San Francisco lean on their respective lead backs, with New York’s duo in a favorable grind. These spots fuel DFS lineups, season-long builds, and prop bets alike.

The Broncos head to Indianapolis aiming to stay undefeated, but Indy’s Week 1 explosion makes this a tougher test. Daniel Jones thrived for the Colts (272 yards, TD) as they scored on all seven possessions, while Denver’s defense pinned the edge with six different players recording a sack. Bo Nix must rebound after two picks and a fumble, while a sharper Broncos ground game from RJ Harvey and J.K. Dobbins adds balance. Alec Pierce’s big-play ability and Indy’s improving defense shape a fantasy-friendly showdown.

Fantasy focus centers on Pierce and Indy receivers, the Broncos’ backfield convergence, and how clean Nix’s decisions can be in a high-leverage road game. If Indy can sustain the same efficiency Jones showed in Week 1, they’ll push Denver in a tight, turnover-prone affair that could swing on a single big play or defensive stop.

Denver aims to flip a historical rough start by opening 2-0, leaning on a veteran defense and a run-heavy attack as Payton rebuilds the offense around Bo Nix. Indy arrives with a refreshed vibe and Daniel Jones orchestrating seven straight scoring drives in Week 1, setting up a clash of Denver’s defensive prowess against Indy’s high-functioning new-look unit.

For fantasy managers, Nix’s turnover risk vs. Indy’s secondary and Jones’ quick-strike rhythm against Denver’s defense are the key storyline drivers. Monitor how the Broncos protect the ball and control pace, while Indy tests Denver’s back-end and pressure at Lucas Oil. Week 2 fantasy pivots hinge on game-script and run/throw balance.

Calvin Ridley enters Week 2 as Tennessee's clear WR1, but his upside is capped by Cam Ward's rookie transition and a Rams defense that was stingy with WRs last week. After a rough opener against Denver, Ridley's floor remains solid in PPR as a mid-range WR3, with limited big-play upside in standard formats. In shallow leagues or if the Titans lean on Week 2 volume, Ridley remains a viable flex option.