Denver opens 2025 with a favorable start, hosting Tennessee in Week 1 and traveling to Indianapolis in Week 2, a setup coach Sean Payton says must be tackled with a fast start to avoid the yo-yo seasons of the past. The Broncos are quietly positioned to sustain momentum after a 10-7 finish and a playoff berth in 2024, but the Week 1 tilt with Tennessee will set the tone for early confidence and fantasy value across Denver’s skill players.

Daniel Jones is pegged to start for the Colts in 2025, a wrinkle that shapes Week 2 when Denver visits Indy. The season-opening storyline centers on acceleration—Payton’s push to begin fast and keep momentum—so fantasy managers should monitor early usage patterns and how both offenses distribute targets and rush attempts in the pivotal opening games.