Broncos’ Week 2 setback vs. Indianapolis spotlighted a run-first spark and a defense needing reinforcements. Denver opened with a hard-nosed, between-the-t tackles run game that freed Bo Nix to connect with Marvin Mims Jr. and set up a pivotal early TD. The offense flashed real upside when Nix and Oregon duo Franklin clicked, but costly penalties and late-game miscues kept this one from turning. Fantasy managers should monitor Nix’s improvisation and Greenlaw’s return for Denver’s LB unit.

Defensively, Dre Greenlaw’s presence is framed as the missing piece to handle tight ends and backs, while the Colts leaned on clock-management that culminated in a late 60-yard winner. Daniel Jones’ late-shot moment and Will Lutz’s miss compounds the volatility of Denver’s fantasy outlook. The night underscored Payton’s aggressiveness, and the potential ceiling lift if Denver can clean up mistakes and ride the Nix–Mims/Franklin connection going forward.