Jacksonville stunned San Francisco 26-21 on the road, riding a punishing ground game and a swarming defense. Travis Etienne ripped 124 yards on 19 carries as the Jaguars controlled pace, while Devin Lloyd shredded the 49ers with two interceptions. Parker Washington erupted on special teams for an 87-yard return, and Arik Armstead’s late sack-fumble sealed SF’s fate. Jacksonville took advantage of turnovers and miscues, turning them into 14 points and a pivotal road win.

The defense held Christian McCaffrey to under 3.0 yards per carry and capitalized on the short fields, with Trevor Lawrence managing the game efficiently and the run game doing the heavy lifting. Special teams provided the dagger, converting field position and a kickoff-return TD to salt away the victory. It’s a statement win that reshapes expectations for both teams entering a heavy weekly slate.

Arik Armstead reflected on the Week 2 hit that sidelined Joe Burrow, stressing he didn’t intend to injure and that he respects Burrow as a top quarterback. He acknowledged a hand in the play that produced a five-yard sack and noted the social-media swirl around the moment. Burrow’s toe injury could sideline him for about three months, changing Cincinnati’s 2025 plans and spotlighting Jacksonville’s defense as a potential fantasy and betting leverage.

The exchange frames a pivotal moment for both teams: the Jaguars’ defensive disruption against Cincinnati and the Bengals’ need to recalibrate without their signal-caller. For fantasy bettors, the development sharpens considerations around Burrow’s backup, target shares, and how the schedule shifts risk and upside across Cincinnati’s skill-position players.