Week 4 injury notes shape Jacksonville vs. San Francisco. Dyami Brown is a game-time call for the Jaguars, with Parker Washington ready to step up if Brown sits. Wyatt Milum and Yasir Abdullah are out or limited, testing Jacksonville's depth. San Francisco welcomes Brock Purdy back, but WR depth is thin with Watkins out and Jennings/Pearsall questionable. If Purdy is limited by injuries elsewhere, SF’s offense could struggle to sustain drives against a disciplined Jaguars defense. Colby, Green, and Jones add interior and secondary depth questions for the 49ers.

Jacksonville elevates Quintin Morris from the practice squad for Week 3 vs. Houston, signaling a blocking-focused TE and added special-teams value rather than a featured receiving role. Ezra Cleveland’s status is pivotal: if he’s able to go, the Jaguars should have enough offensive linemen to protect against the Texans’ pass rush; Milum’s ruled-out status tightens depth, making the decision to activate Morris a hedge against a potential seven-man OL scenario and a limited 47-active-player cap.

Jaguars flip the script for Week 3 vs Houston as Montaric Brown eyes a 2025 debut off an ankle rehab, joining a rotating corps with Jarrian Jones and Travis Hunter as Jacksonville weighs how to reintegrate him. Milum is out, Cleveland questionable, complicating line and secondary depth. Texans counter with CJ Stroud fueling Nico Collins in a 14 PPG attack, a unit capable of striking if the Jacksonville defense blinks.

Texans and Jaguars open Week 3 with a mix of returns and setbacks. Houston sees Lassiter and Pitre limited in practice, while Kirk and Braxton Berrios appear on track to debut after Week 1–2 absences; Jake Andrews returns to practice in limited fashion. Jaylin Smith remains DNP. Jacksonville lists Ezra Cleveland DNP, but Brian Thomas Jr. is a full participant; Bhayshul Tuten and Wyatt Milum limited with Montaric Jones full. Week 3 hinges on practice progress and who suits up.