Jacksonville heads into Week 5 against Kansas City with optimism that Liam Coen’s offense can unlock Trevor Lawrence and the Jaguars’ arsenal. Lawrence could post his best fantasy day of the season as Jacksonville tries to keep pace with Mahomes and the Chiefs. BTJ has shown progress and could seize the moment against a middling KC secondary, while ETN continues to be the steady fantasy engine. The matchup hints at a potential shootout that could redefine Jacksonville’s fantasy ceiling in 2025.

Expect Lawrence to lean on downfield threats if the protection holds, BTJ to turn a favorable matchup into a multi-catch day, and ETN to once again smash double-digit fantasy points. If Coen’s scheme clicks, Week 5 could mark a turning point for fantasy managers riding the Jaguars’ offense.

Travis Etienne is projected by SportsLine's ML model to exceed 70 rushing yards against Kansas City, with a +110 price at FanDuel. The Jaguars sit at 3-1, and Etienne has cleared 70 rushing yards in 3 of 4 games this season, aided by Jacksonville's prolific ground attack. The model also flags Tyquan Thornton as an anytime TD scorer (+400) for Kansas City and Brian Thomas Jr. as a +185 TD scorer for Jacksonville, with Thomas slated for solid receiving work.

These Week 5 projections frame a value-packed slate around cross-team bets, highlighting Etienne's 71-yard projection, Thornton's scoring upside, and Thomas Jr.’s receiving role. Promotions from Caesars and DraftKings are noted alongside FanDuel’s +110 on Etienne, underscoring compelling leverage in a Chiefs-Jaguars showdown.

Kansas City seeks its first opening-drive TD of the season as it hosts Jacksonville, with Mahomes stressing quick points to ease pressure and help finish games. Spagnuolo’s defense is framed as a finisher, leveraging varied looks late to seal outcomes.

Etienne’s 124-yard, TD performance last week highlights his ceiling against KC, while Derrick Henry’s big-play danger lingers as KC looks to bottle him up. The matchup hinges on drive efficiency and discipline, with fantasy managers eyeing Etienne’s workload and KC’s finish ability.

Expect a tactical, run-focused clash where early momentum and closing discipline could tilt fantasy rosters toward the players who influence those sequences.

Chiefs visit Jaguars on MNF as KC seeks to extend momentum after a 2-2 start, while Jacksonville tries to capitalize on a turnover-driven surge and a efficient run game. Mahomes remains the engine, but Jacksonville’s defense has flipped the script with takeaways and stout run defense, giving Trevor Lawrence and Travis Etienne ample opportunities to produce in a lower-total, clock-management affair. The model leans toward a sub-45.5 point night with KC favored, demanding smart lineups that leverage turnover volatility and game pace.

Fantasy managers should eyeball Mahomes as a high-floor play, while Lawrence offers contrarian upside in a game that could hinge on ball-security and first-down efficiency. Etienne’s workload and the Jaguars’ ground attack could keep Mahomes off the field enough to create leverage in GPPs. With Jacksonville’s defense generating takeaways, speculative WRs/TEs in KC and JAX provide salary relief and upside as pass-catching options in a potentially grindy Monday night showdown.

Week 5 Monday Night Football features Kansas City visiting Jacksonville in a likely high-scoring showdown (Total 45.5, KC -3.5). Xavier Worthy returns to a clearer target role for Kansas City with Rashee Rice suspended, making him a solid WR2 option as the Chiefs lean on Mahomes, Kelce, and Etienne remains a steady RB2 for Jacksonville.

Key decision points center on whether Brenton Strange can sustain TE2 value against KC, how Brian Thomas Jr. grades out vs Trent McDuffie, and if Worthy edges out Thomas in fantasy lines. KC’s defense and Butker look like safe plays, while Hunter is usually a sit. Build around the obvious stars and temper expectations for some ancillary pieces in Week 5.