Christian McCaffrey calf concerns loom as weekend injury updates roll in. Kyle Shanahan downplays the issue, but calf history keeps fantasy managers cautious, nudging projections toward a smaller CMC workload if he’s limited. Expect SF to lean on George Kittle and Deebo Samuel, with a possible backfill in the run game if McCaffrey sits. Jerome Ford could seize Week 1 Browns work, while Amari Cooper’s retirement adds a big-picture shift for Cleveland’s targets. Mooney and Collins are day-to-day for Houston and Chicago, respectively, keeping Week 1 depth uncertain.