Jaguars head coach Liam Coen faces a stern road test in San Francisco as Jacksonville looks to keep pace with a 49ers squad that has started 3-0. Bhayshul Tuten could earn a bigger rushing role as Jacksonville leans on efficiency over volume. Purdy's big-plays and Ricky Pearsall downfield threat loom for the defense, while the Jags aim to bottle McCaffrey and slow SF's rushing attack.