Denver and San Francisco collide in a preseason showcase that doubles as a fantasy predictor. Bo Nix and a shorthanded Broncos offense are expected to lean on two-way rookies and depth pieces as they test schemes against San Francisco’s rotation. San Francisco won’t ride its veteran starters heavily, instead leaning on rookies and depth players, with Mykel Williams, Corey Kiner and Jakob Robinson among the players set to push for roles. Ricky Pearsall could emerge as a sleeper, while Denver’s depth pieces look to prove themselves for the regular-season depth chart.

Key fantasy takeaways hinge on workloads rather than traditional box-score lines. Nix’s ceiling remains tied to playmakers stepping up, Pearsall’s connection potential, and the SF rookies seizing backups’ opportunities. The absence or limited participation of stars like McCaffrey, Purdy, and Bosa amplifies the value of depth players who could become week-to-week flex plays or dynasty adds. Monitor rookies on both sides who could move into real-season roles if opportunities arise in this game.

The San Francisco 49ers are adjusting to a significant change in their linebacker corps after losing Dre Greenlaw to the Denver Broncos and De'Vondre Campbell, who remains unsigned. In response, the team has bolstered its lineup by acquiring veterans Luke Gifford and Chazz Surratt while also drafting promising linebacker Nick Martin from Oklahoma State. Martin showcased impressive skills during offseason practices, suggesting he could compete for a starting position alongside Fred Warner. However, a recent injury resulted in a broken bone during training, raising concerns about his readiness for the upcoming season and the depth of the 49ers' defense.

The San Francisco 49ers have made a significant push to enhance their financial flexibility by offloading 17 players this offseason, resulting in an NFL-high dead cap hit of $92,651,013. This decision reflects a strategic shift, aiming to streamline their roster and improve future salary cap management. Notably, the Philadelphia Eagles follow closely with a dead cap figure of $71,991,237 after their recent trades.

Among the notable 49ers released are Deebo Samuel, Arik Armstead, and Leonard Floyd, all of whom considerably impact the team's cap space. This move showcases the 49ers' commitment to establishing a more financially sustainable roster while potentially unlocking future acquisitions or contract extensions for their remaining core players.

In recent years, the San Francisco 49ers have thrived with a formidable pass rush. However, the 2024 season saw a dip, ranking 18th in the NFL with a mere 6.69% sack rate. In an effort to revitalize their defense, the 49ers focused heavily on the 2025 NFL Draft, selecting defensive end Mykel Williams at 11th overall. ESPN's Ben Solak has predicted that Williams will win the Defensive Rookie of the Year award if deployed effectively and stays healthy. His potential to dominate opposite Nick Bosa could lead to a breakout season, potentially surpassing his college high of five sacks. The 49ers also made minimal additions to their roster, mainly retaining key players while parting ways with others like Leonard Floyd and De'Vondre Campbell.

The San Francisco 49ers made a strategic move in the 2025 NFL Draft, selecting linebacker Nick Martin from Oklahoma State with their 75th overall pick. The decision comes on the heels of significant changes in their linebacker corps, particularly with the departure of Dre Greenlaw to the Denver Broncos and the addition of Luke Gifford to Robert Saleh's defense. With Fred Warner leading the unit, the 49ers sought depth at the position as they head into the upcoming season.

Martin, a former three-star recruit, had an impressive college career, wrapping up his four years at Oklahoma State with a total of 203 tackles, including 24 for loss, alongside seven sacks. His ability to disrupt plays and contribute in various defensive roles likely played a key factor in his selection, as the 49ers aim to maintain a strong defense in light of recent roster changes.