Jauan Jennings returns to 49ers practice after calf injury and a suspected contract holdout, setting the stage for an unsettled Week 1 at Seattle. His reintroduction comes with questions about speed, route timing, and overall conditioning after limited camp time. The SF offense may lean on Deebo Samuel, Brandon Aiyuk, and George Kittle early, while Jennings works to regain his role and trust in the offense.

Historical holdouts suggest a cautious ramp, and the calf risk adds another layer of risk for fantasy managers. If Jennings isn’t fully back by Week 1, Seattle’s defense could clamp down, making Jennings a risky Week 1 option with potential to trend up as he proves he’s fully operational in the following weeks.

Ricky Pearsall is under real pressure to be the 49ers’ Week 1 spark in 2025. With Brandon Aiyuk likely out four to six games and Jauan Jennings dealing with a calf issue, Pearsall faces a featured role early, surrounded by Russell Gage and Marquez Valdes-Scantling. A productive start could unlock SF’s ceiling; a slow one could derail the early schedule against Seattle and New Orleans. The offense’s success hinges on Pearsall’s progression and how quickly the other top receivers return to form.

His 1.31 yards per route run screams inefficiency, but the late-season surge showed what he can do when given targets. If he builds on that momentum and translates it to a more demanding role against sharper cornerbacks, the 49ers could turn a potentially rough start into “best offense in the NFL” momentum as Aiyuk, Jennings, and Robinson rejoin the lineup.

Keenan Allen’s return to the Chargers brings experienced reliability for fantasy depth, projected as WR55 with WR4 upside if fully healthy. Nick Chubb joined Houston, but his fantasy value hinges on how his knee and foot injuries progress and how Houston allocates workload, possibly dialing back expectations. Kenneth Walker III and Jakobi Meyers offer upside as early-round contributors, while Rome Odunze steps into a clearer WR2 role in Chicago behind an improving line. Keon Coleman and Ladd McConkey present boom-bust options with high ceiling in Buffalo and Los Angeles, respectively. Jauan Jennings, Chris Olave, Keon Coleman, and Tyreek Hill anchor the receiver corps, with Hill remaining elite; the rookie Keon Coleman and Odunze carry late-round intrigue.

Tank Bigsby adds rookie flare as a tangible upside pick, and Keenan Allen’s health and Herbert familiarity could unlock an immediate, steady floor. The tool’s projections emphasize targeted depth and upside across the board, guiding savvy managers to balanced builds for 2025 drafts.