Isaiah Prince left San Francisco's preseason finale with a left‑leg injury, casting doubt on the 49ers' early depth at offensive tackle as rosters tighten. With Prince potentially sidelined, Austen Pleasants, Spencer Burford, and Nick Zakelj figure to absorb extra work and shape the Week 1 line, which in turn could impact run blocks and pass protection for the backfield.

Burford’s versatility, Zakelj’s length, and Pleasants’ depth role become fantasy-relevant if Prince misses time, since any extended absence could shift linemen roles and influence SF’s early-season efficiency in both the run game and the pass game. Managers should watch Prince’s timeline and any IR chatter as cuts loom.

The Titans’ roster shuffle persists beyond a preseason loss, but starters largely keep their spots as depth-chart adjustments roll out after Game 1. With joint practices in Atlanta looming and a Aug. 15 tilt vs. the Falcons, The Tennessean’s Post-opener 53-man projection tightens the bottom of the roster, emphasizing an adaptable group ready for Week 1. The moves center on depth, special-teams value, and contingency plans for injuries, while the core—especially the top skill-position players—stays intact.

In the backfield, Tony Pollard anchors the RB group, joined by Tyjae Spears, Julius Chestnut and Kalel Mullings, giving Tennessee insurance behind Pollard and a pathway if Spears isn’t 100% by Week 1. At receiver, Calvin Ridley, Van Jefferson and Tyler Lockett hold the top lines, with Elic Ayomanor, Chimere Dike, Bryce Oliver and James Proche II filling the four- and return-man roles to create a multi-faceted package in the passing game. The tight end grouping features Chig Okonkwo, Gunnar Helm and Thomas Odukoya, with Josh Whyle breathing down the depth chart late in the opener but needing to earn his place.

On the line, the Titans carry nine blockers—Moore, Skoronski, Cushenberry, Zeitler, Latham, Levin, Hance, Rupcich and Slater—balancing health and versatility for Week 1 and potential swing-tackle needs. Up the middle, five interior defenders (Simmons, Sweat, Joseph-Day, Lynch, Raikes) provide a mix of star power and insurance. The edge group (Jones, Key, Oladejo, Ali Gaye, Ward) remains fluid, with Jihad Ward edging Jaylen Harrell for the last spot after productive pressure in the opener. In the middle, four linebackers (Barton, Williams Sr., Gray, Jacobs) hold ground against waivers and practice-squad churn. In the secondary, seven corners (Sneed, Brownlee Jr., McCreary, Baker Jr., Harris, Jeudy-Lally, Oruwariye) and four safeties (Hooker, Woods, Winston Jr., Mike Brown) give Tennessee ample nickel and dime flexibility, while Diggs’ status looms as health and matchups dictate. Special teams are set with Cox, Hekker and Slye staking the 53, giving Kermin confidence as the unit builds chemistry for September.

The Los Angeles Rams have established a notable defensive legacy, marked by some exceptional single-game records. Aaron Donald, a standout among legendary defenders, holds numerous records, including the highest tackles for a loss in a game (6) and multiple records for quarterback hits (6). Other notable single-game performances include James Laurinaitis, Alec Ogletree, and Mark Barron, each achieving 16 tackles. Gary Jeter set the record for most sacks in a game at 5.0, and Janoris Jenkins achieved two pick-sixes in a game, showcasing the Rams' defensive prowess.

The Tennessee Titans are set to face the Houston Texans in Week 12, but they will be without four players. Running back Tyjae Spears is sidelined due to concussion protocol, while offensive tackle Leroy Watson IV is out with a back injury, leading to Nicholas Petit-Frere starting again.

Cornerback Gabe Jeudy-Lally and tight end David Martin-Robinson are healthy scratches, with Martin-Robinson yet to make his debut this season. The Texans have also ruled out several key players for the matchup.