Buffalo Bills enter Week 5 with Ed Oliver and Matt Milano sidelined, and Spencer Brown and AJ Epenesa possibly limited. Dorian Williams steps in for Milano, while Deone Walker takes Oliver's snaps. If Brown cannot play, Ryan Van Demark would start. The Bills sport a 15.5-point spread against New Orleans and own a 13-game regular-season home win streak, underscoring depth concerns and the fantasy implications of expanded roles for Buffalo’s reserves.

Fantasy angles center on Williams' increased snaps and Walker's interior workload, plus potential shifts on the line if Brown sits. The Saints' attack could test a thinner Bills front, making late-week projections and snap counts critical for DFS lineups and IDP considerations as Buffalo leans on depth to hold a dominant home-field streak.