Milano's return shores up Buffalo's defense for the Week 5 primetime clash with New England, but interior depth is thin with Ed Oliver and TJ Sanders out and Dorian Williams inactive. Landon Jackson will debut, while Zion Logue and Phidarian Mathis join the DT rotation. Curtis Samuel earns a jersey as Elijah Moore remains inactive, and Samuel/Khalil Shakir provide return opportunities with Johnson handling kicks. Jimmy Ciarlo is active after a late roster move.

Fantasy angles center on how Logue/Mathis anchor the interior and whether Jackson can spark the edge rush, plus how Samuel, Johnson, and Shakir contribute in return duties and short-yardage packages against New England.

Patriots-Bills Week 5 inactives reshape fantasy expectations. Carlton Davis and Milton Williams are active, anchoring New England’s secondary and interior line as Jahlani Tavai returns. K'Lavon Chaisson is out, likely boosting Keion White’s rush opportunities against Josh Allen. Efton Chism III remains inactive, stalling rookie WR upside.

Bills list Elijah Moore, Ed Oliver, Dorian Williams, Jordan Hancock, Brandon Codrington, Chase Lundt, and T. J. Sanders as inactive, signaling clearer target trees and fewer interior disruptors for Buffalo. Snap and scheme shifts could tilt value on both sides, especially for edge rushers and defensive units in DFS.

Buffalo's 2025 rookie grades after four games reveal a broad range of impact. Hairston sits with an incomplete due to a knee injury and a 21-day practice window looms. Sanders has shown pass-rush potential with six QB pressures but no sack yet. Landon Jackson has stayed healthy but hasn’t earned a jersey. Deone Walker has been the standout, flashing both 1-tech and 3-tech versatility. Hawes has been a solid contributor as a blocking tight end with receiving upside; Hancock and Lundt have limited snaps; Prather was waived after an injury. Ed Oliver's injury has shaped the defensive rotation, and the Week 4 Saints game offered a clearer view of Buffalo's depth. Beane’s class blends immediate depth with upside, even as some top picks wait for a window to contribute.

Spencer Brown is inactive with a calf injury, forcing Buffalo to start Ryan Van Demark at right tackle in Week 4 against the New Orleans Saints. That shift up front could affect both the Bills' run blocking and Josh Allen's time in the pocket, shaping Cook's opportunities and the offense's overall ceiling. A.J. Epenesa is active after a pectoral scare, bolstering Buffalo's pass rush while several veterans are out or limited on defense. Buffalo also promotes rookies Jordan Hancock and Chase Lundt to debut, and Curtis Samuel returns to action for Washington.

Additional notes show Ed Oliver and Matt Milano sidelined, narrowing interior disruption and linebacker play. The kick and punt return duties face questions with Brandon Codrington inactive. The Saints pose a non-conference test, and Buffalo’s depth will be tested across both lines and special teams as fantasy managers gauge Cook’s workload and Allen’s production in a new front‑five environment.

In this Week 4 scenario, the Bills’ fantasy outlook hinges on Cook’s volume and Buffalo’s ability to protect Allen in Brown’s absence. This matchup will also spotlight the Bills’ rookie playmakers and how quickly they can contribute to obstacles created by injury and rotation, with several defensive gaps potentially impacting scoring opportunities in a game that has clear fantasy implications.

Buffalo Bills sit Taron Johnson in Week 2 as Tre'Davious White returns, bolstering a secondary facing a run-heavy Jets attack. Buffalo could lean into three linebackers to counter the ground game, while Ed Oliver is ruled out and Zion Logue and Keonta Jenkins prepare for season debuts via practice-squad elevations. Curtis Samuel is a healthy scratch again, with Landon Jackson and Chase Lundt inactive alongside Shaq Thompson and Jordan Hancock. Kickoff is 1 p.m. ET on CBS.