Milano's return shores up Buffalo's defense for the Week 5 primetime clash with New England, but interior depth is thin with Ed Oliver and TJ Sanders out and Dorian Williams inactive. Landon Jackson will debut, while Zion Logue and Phidarian Mathis join the DT rotation. Curtis Samuel earns a jersey as Elijah Moore remains inactive, and Samuel/Khalil Shakir provide return opportunities with Johnson handling kicks. Jimmy Ciarlo is active after a late roster move.

Fantasy angles center on how Logue/Mathis anchor the interior and whether Jackson can spark the edge rush, plus how Samuel, Johnson, and Shakir contribute in return duties and short-yardage packages against New England.

Patriots-Bills Week 5 inactives reshape fantasy expectations. Carlton Davis and Milton Williams are active, anchoring New England’s secondary and interior line as Jahlani Tavai returns. K'Lavon Chaisson is out, likely boosting Keion White’s rush opportunities against Josh Allen. Efton Chism III remains inactive, stalling rookie WR upside.

Bills list Elijah Moore, Ed Oliver, Dorian Williams, Jordan Hancock, Brandon Codrington, Chase Lundt, and T. J. Sanders as inactive, signaling clearer target trees and fewer interior disruptors for Buffalo. Snap and scheme shifts could tilt value on both sides, especially for edge rushers and defensive units in DFS.

The Bills lean on efficient, mid-range passing and yards after catch to power a top offense. Josh Allen takes what defenses give and will push for downfield shots when opportunities arise, but the game plan centers on yak-enabled scores and steady production rather to explosive plays. Buffalo’s fantasy floor remains high as Moore, Shavers, Shakir, Knox, and Kincaid convert catches into consistent yardage and scores.