Buffalo erased a 15-point fourth-quarter hole to beat Baltimore 41-40 in Week 1, led by Josh Allen’s late MVP-level surge and a breakout by Keon Coleman. Ed Oliver sparked the defense with a strip that flipped momentum and helped set up Buffalo’s dramatic finish. The offense piled up 497 yards as the passing game finally opened with big plays downfield, while the Bills’ secondary remains a lingering concern heading into Week 2.

Allen finished 33 of 46 for 394 yards with two passing touchdowns and two rushing scores, Coleman hauled in eight catches for 112 yards and a TD, and Oliver delivered a game-changing performance with five-plus impactful stops, a sack, and the forced fumble. With KC’s opener losses, Buffalo starts the season bold and dangerous, pending defensive consistency against high-caliber offenses.

Prime-time Week 1 pits the Bills against the Ravens in Orchard Park with three Bills prop bets catching fantasy eyes. Dawson Knox to score anytime at +500, Keon Coleman at 40+ receiving yards, and James Cook at 60+ rushing yards headline the slate on DraftKings. Allen’s trust in Knox remains a factor, Coleman looks like a Year 2 breakout candidate, and Buffalo’s run game should stay balanced as they open NBC’s SNF slate.

The bets hinge on Knox’s red-zone chemistry with Allen, Coleman’s growing route discipline, and Cook’s capacity to grind out yards behind a cohesive line and a Bills offense that often leans on multi-pronged attack in primetime.

Buffalo Bills Week 1 depth chart highlights Cole Bishop as a starting safety, pairing him with hampered injuries in the secondary. DeWayne Carter lands on season-ending IR, trimming theDT depth to Oliver, Jones, Sanders and Walker. Landon Jackson backs up Bosa, while Javon Solomon sits third behind Rousseau and Epenesa. At linebacker, Milano anchors, Williams emerges as a first-teamer, and Williams’ role remains fluid in a nickel-heavy scheme. Special teams lean into rookie versatility and a stable kicking/punting setup.

Buffalo sits near the top of NFL power rankings entering 2025, led by Josh Allen’s MVP-caliber ceiling, a bigger workload for James Cook, and a defense anchored by Ed Oliver and Christian Benford. Maxwell Hairston’s potential early impact adds back-end depth as Buffalo readies for Week 1 against Baltimore. The Bills’ blend of explosive offense and a more cohesive stop unit keeps them squarely in the AFC title mix.

Across outlets, Buffalo’s momentum is clear: strong offense, improved defense, and a favorable path in the division, though questions linger about secondary consistency in top matchups. For fantasy, Allen’s volume and Allen-driven big plays, Cook’s growing touches, and the defense’s upside plus Hairston’s ceiling give Bills players premium upside in 2025.