The Buffalo Bills made another strategic move during the 2025 NFL Draft, trading up to pick 109 in the fourth round to select Deone Walker, the Kentucky defensive tackle. In the trade with the Chicago Bears, the Bills exchanged their fourth-round pick (132) and a fifth-round pick (169). This highlights the Bills’ continued focus on bolstering their defensive line.

Walker stands out with his impressive stature at 6-foot-7 and 331 pounds, addressing the Bills' need for a dominant 'space eater' in the middle. He had a strong collegiate career with 132 tackles, including 23 for loss and 10 sacks, indicating his potential to significantly impact the NFL.