Josh Allen stands out as an elite quarterback in fantasy leagues, consistently ranked as the top option in drafts. His ability to stay healthy and perform at a high level makes him a safe investment for fantasy managers, despite concerns over opportunity cost when choosing between a quarterback and a running back. With impressive stats over the years, including significant rushing yards and touchdown production, he remains a premier fantasy asset.

James Cook emerges as an intriguing running back option, currently ranked as RB14. His potential for increased involvement in the Bills' offense is a topic of interest, especially when considering his draft position compared to other running backs. While the wide receiver corps may not be the most reliable for fantasy points, Allen's ability to spread the ball adds mystery to their value. The overall season outlook for the Bills hinges on Allen's performance and the supporting cast’s ability to capitalize.