The Buffalo Bills are poised for another run at the AFC East title, riding a wave of success with five consecutive divisional championships. To maintain their dominance in the 2025 season, three critical factors will influence their ability to defend this title.

First on the list is James Cook's contract situation. As an impactful player with multiple Pro Bowl selections, Cook is currently seeking a new deal. His performance in the backfield has been vital, and securing his future in Buffalo could bolster the team's chances. Additionally, the offensive line's ability to protect quarterback Josh Allen and create running lanes will be essential. Lastly, the Bills' health, particularly regarding key injuries, will be a determining factor in their quest to extend their divisional title streak.