Buffalo hosts New Orleans in Week 4 with a pristine 3-0 start, while the Saints sit at 0-3 after a rough cross-country trip. Vegas pegs the Bills as heavy favorites, and the forecast favors a clean controlled game for Buffalo. Key injuries loom on both sides, notably Milano and Oliver missing time for Buffalo, and Chase Young out for New Orleans, pinning the game plan on depth, matchup exploitation, and early execution.

Kamara and Olave must spark the Saints’ offense as Spencer Rattler grows into the starting role, while Buffalo leans on a high-snaps workload for Joey Bosa and a rested defensive front if the scorelines break Buffalo’s way. Dorian Williams steps into a larger role, and McDermott’s crew will look to pressure and contain while preserving stamina for a playoff push.

Expect a Bills’ fast start to set the tone, with Allen orchestrating scoring drives and a defense that clamps down on third downs. The Saints need a balanced attack, but without their top pass rusher, the path to a comeback becomes steeper. A controlled Buffalo win seems likely, but fantasy angles will hinge on Kamara, Olave, and Williams’s impact.

In DFS terms, target Kamara as a contrarian piece if volume rises, monitor Williams for big-tackle upside, and consider Bills’ defense as a top streaming option if New Orleans stalls out of the gate. The game environment, with warm weather and light winds, supports a higher-scoring kickoff for Buffalo, who aim to cover the spread and keep their undefeated streak intact.