James Cook is the Bills' engine, posting 237 yards from scrimmage and 5.2 YPC through two games with three rushing TDs, turning tough runs into long gains and keeping Buffalo's offense rolling.

Keon Coleman lauds his vision and balance; Josh Allen calls him an absolute stud who makes the team better, while Cook signed a four-year extension in August and looks primed for prime form with two prior 1,000-yard seasons on his resume.

His early pace hints at high-end fantasy upside if workload stays steady, making Cook a prominent target in season-long and DFS lineups as Buffalo leans on the run-game punch.

Buffalo’s high-octane offense (35.5 ppg) hosts a reeling Miami squad that has yielded 33 points in each of its first two games. Buffalo is a 12-point favorite with a 49.5-point total, and simulations peg Buffalo to cover roughly 57% of the time and the Over around 67%. Expect Josh Allen to pace a shootout against Miami’s vulnerable defense, while Miami’s healthy Tua Tagovailoa tries to keep pace for fantasy managers.

Buffalo owns a commanding recent edge, winning 13 of 14 meetings (including playoffs). Kickoff is 8:15 p.m. ET at Highmark Stadium. The game sets up as a strong fantasy play for Bills pass-catchers and a challenging but intriguing option for Dolphins, with the betting line and model leaning toward a high-scoring, Buffalo-led night for Week 3.

Week 3 fantasy preview centers on elite ceilings and cleanly favorable matchups. Josh Allen faces a Dolphins defense that has shown vulnerabilities, making Allen a top QB staple this week. Drake Maye keeps pushing in a favorable Pitt matchup, while Bijan Robinson awaits a run-friendly date with Carolina. Jahmyr Gibbs and David Montgomery carry Week 3 upside against Baltimore, with Jefferson and Boutte delivering high-target potential against weaker pass defenses. Sam LaPorta and Jake Ferguson offer solid streaming TE options, and Nabers remains a flexible play against Kansas City. Jaxon Smith-Njigba and Cooper Kupp provide strong stacks in the right games. Derrick Henry’s spot versus Detroit remains nuanced, but upside exists in short-yardage and goal-line packages.

Two-paragraph summary: Allen’s Week 3 ceiling centers on a shootout pace in Miami, backed by Bills’ balanced attack. Maye’s growth continues as New England leans into his dual-threat ability against Pittsburgh, while Robinson’s Carolina matchup anchors a safe volume floor for Week 3. Jefferson’s move to feast against Cincinnati hinges on evolving chemistry with Wentz, and LaPorta’s mid-range TE appeal grows as Detroit leans into the air game to counter Baltimore. The slate rewards lineups that combine high-volume RBs, clearWR targets, and efficient streaming TEs in favorable matchups.