Buffalo hosts Baltimore in Week 1, a marquee clash of two MVP QBs and top offenses. Buffalo targets tempo with Dalton Kincaid, Keon Coleman, Josh Palmer, and James Cook, while Allen seeks comfort against Baltimore’s defense.

Baltimore counters with Derrick Henry and a rugged front, aiming to slow Buffalo’s pace and force tough, clock-eating drives. The game carries seeding and home-field implications, making early fantasy production pivotal.

Fantasy takeaway: lean Bills pass-catchers and Cook; Kincaid’s role grows with the new weapons, while Baltimore’s run game and Henry may temper upside for Buffalo’s backfield in Week 1.