Khalil Shakir is positioned as Buffalo’s top pass catcher in Week 1 after Diggs’ departure, with the Bills’ offseason additions not materially threatening his target share. Shakir broke out in 2024 (76 receptions, 821 yards, 4 TDs on 100 targets) and enters 2025 with clear WR3/flex value in a high-octane Bills offense. An ankle scare in camp didn’t derail three straight full practices, setting him up for a favorable matchup against Baltimore’s playoff-caliber offense in a potential shootout.

Buffalo’s depth chart remains lean beyond Shakir, with Joshua Palmer adding veteran presence but not monopolizing targets. Josh Allen’s ceiling remains sky-high, and Shakir’s involvement should keep him in fantasy lineups as a strong flex in Week 1, especially in formats that reward catches and yards. Expect big-play upside and a hefty target floor if the Bills lean on him early against Baltimore.