The Buffalo Bills' defense is anticipated to be one of the league's top units this season, featuring young talents paired with established Pro Bowl players. However, the team faces significant challenges as they prepare for the upcoming year. The suspensions of defensive linemen Michael Hoecht and Larry Ogunjobi have raised concerns about the depth and effectiveness of the defensive line. Additionally, the Bills made a substantial investment in their defense during the draft, selecting six defensive players out of nine total picks, indicating a clear focus on strengthening this area.

On top of these suspensions, the absence of edge rusher Joey Bosa due to injury further complicates the situation. The combination of recent suspensions and injuries has led to a cloud of uncertainty hanging over the defensive unit, making it clear that despite their potential, performance and cohesion will heavily depend on how quickly the team can adapt to these setbacks.