Buffalo visits Chicago for Week 2 of the NFL preseason at Soldier Field with Buffalo’s wideout corps still banged up. James Cook’s contract extension adds a clear signal about backfield usage, but exact Sunday reps are up in the air as Buffalo balances risk with opportunity in a tune-up game.

Banks of depth pieces for Buffalo—Laviska Shenault Jr., Jalen Virgil, Deon Cain and Stephen Gosnell—are primed to operate as the immediate next targets behind Cook, especially if the Bills’ WR room remains thin. Chicago’s defense will test Bears-level depth from Coleman, Virgil, Cain, Kristian Wilkerson, Shenault and Gosnell, while Cook’s extension could tilt early-season plans toward a heavier usage in the backfield if pass-game options stay limited.

Television and streaming paths are straightforward: FOX local channels, a 7 p.m. ET kickoff, and options like NFL+, the NFL app and partner services for streaming. Fantasy managers should watch for Cook’s workload cues and the emergence of Shenault, Virgil, Cain and Wilkerson as potential Week 2 contributors in Buffalo’s pass game.

Fantasy takeaway: Cook’s contract extension tightens the leash on early-season usage, while Bills WR injuries raise the floor for Shenault and Virgil as depth options. This game should offer valuable Saturday-night hints on how Buffalo will divvy targets behind Cook and who steps up when the top receivers are limited.