The Week 1 SNF showdown between the Ravens and Bills centers on Isaiah Likely's Week 1 status, as he’s recovering from a broken bone in his foot and isn’t expected to play. That narrows Baltimore’s two-TE threat behind Mark Andrews and pushes fantasy focus toward Andrews and the Ravens’ pass-game components, with Lamar Jackson still a prime rushing engine. Buffalo, getting Matt Milano back, can better defend tight ends and curb some of Baltimore’s TE-driven mismatches, while still facing Jackson’s ground game.

With Likely out, Baltimore may lean more on Andrews and his peers at WR/RB to absorb targets, while Buffalo’s defense aims to slow the rushing attack and TE-driven plays. This Week 1 SNF tilt hinges on Ravens’ adaptation without Likely and Bills’ ability to modernize pass coverage against tight ends, complicating early-season game plans for fantasy managers.