Week 1 brings Buffalo at Baltimore under prime-time lights, and fantasy managers will be watching three one-on-one battles that could tilt the narrative. Rashod Bateman faces the Bills’ upcoming CB2, while Matt Milano slides into Derrick Henry’s path in the opener. Odafe Oweh vs Spencer Brown caps the trio, a pair of edge duels that could set the tone for the first fantasy indicators of the season.

Bateman’s separation, Henry’s power, and Oweh’s sack potential shape not just the game flow but which players push into top-12 territory in weekly lineups. Brown’s blocking against Baltimore’s fearsome pass rush could swing Buffalo’s play-action and run game. The outcomes of these matchups will guide Week 1 value across fantasy teams.

Expect high leverage plays in the passing game, a few big plays against CB2, and a night where the defensive lines set the tempo. In short, these three matchups will tell you where early season fantasy upside and risk live in this divisional rematch.