Buffalo's 2025 outlook centers on an elite offensive line returning four starters, a versatile backfield trio, and a defense that now includes Joey Bosa and Michael Hoecht to bolster the pass rush. Terrel Bernard and Matt Milano form a top LB pairing, with Dorian Williams providing upside behind them. Safety depth is a notch below elite, but Hamlin and Poyer offer leadership. Week 1 against Baltimore will test run control and secondary depth, while fantasy angles lean toward Cook's workload, the DL's sack upside, and OL stability.