Derrick Henry’s power meets Buffalo’s young interior in a Sunday night showdown with Baltimore. Henry’s size-speed blend keeps Buffalo’s rookie tackles TJ Sanders and Deone Walker honest as Baltimore leans on the offensive line to create lanes and leverage. Baltimore’s offense, spearheaded by Lamar Jackson, can threaten you with downhill runs or spread you out, forcing Buffalo to swarm and scrape to the ball. Terrel Bernard, Matt Milano, and Taylor Rapp anchor Buffalo’s run defense, with Cole Bishop stepping in as a versatile rover behind them.

Buffalo’s challenge is real: Henry has posted massive yardage behind strong lines before, and Baltimore’s scheme can flip tempo at a moment’s notice. Buffalo counters with veteran leadership and a dynamic secondary that must ride run fits and communication, especially against play-action and misdirection. The night should tilt toward disciplined gaps and active pursuit, with Henry poised to influence fantasy lineups through volume and goal-line appearances despite the Bills’ best efforts to limit him.