Handcuff running backs remain a cornerstone of savvy fantasy rosters, and 2025 could hinge on three overlooked backups stepping into starter-level upside when injuries strike. Ray Davis in Buffalo backs James Cook and sits at RB42 in high-stakes drafts, presenting solid RB3 value with legitimate bye-week and emergency-start upside. Will Shipley in Philadelphia looks locked in as Barkley’s clear-to-fill RB2, a contingent piece who could rise if Barkley misses time. DJ Giddens in Indianapolis offers speed and receiving ability behind Jonathan Taylor, with a real 50/50 shot at live-action work in relief duties. Together, they form a compact trio of late-round, high-upside handcuffs who could rescue fantasy squads when the season twists.