The Week 6 NFL slate closes with Patrick Mahomes and the Kansas City Chiefs hosting Jared Goff and the Detroit Lions in a high-profile, spread-tight showdown (Chiefs -2.5, 52.5 total). Monday brings a doubleheader: Bills at Falcons and Commanders at Bears, with sharp lines and bold promos driving action. The betting model leans Lions to stay within reach, Bills to cover more often, and Washington to handle Chicago, shaping DFS and prop bets across the board.

Keon Coleman faced a Week 5 benching for disciplinary reasons but rebounded with a late TD and several clean catches against New England, signaling growth and resilience.

Through five weeks, Coleman sits among Buffalo's top receivers (226 yards, 2 TDs) and remains a high-upside, high-variance fantasy play as the Bills push for consistency in a tougher schedule.

Dalton Kincaid’s Week 6 status is murky after a limited Thursday practice with an oblique tweak as Buffalo heads to Monday Night Football against Atlanta. He’s the Bills’ leading receiver with 287 yards and has TDs in three of five games, making his availability critical for fantasy lineups.

Several Bills bodies are dealing with bumps, with Milano and Sanders out or limited and Dawkins, Hamlin, Rapp, Williams, and Oliver in limited work. Jackson Hawes was limited last week but is no longer on the injury report, signaling possible shallow depth returns behind Kincaid.

The situation adds volatility to Buffalo’s Week 6 plans and could push more targets to complementary playmakers or spike Hawes’ role if Kincaid sits. McDermott’s one-day-at-a-time approach keeps fantasy managers on alert for Monday’s game in Atlanta.