Buffalo and Chicago square off in Week 2 of the NFL preseason with a nationally televised tilt that features a familiar exchange of quarterbacks and roster depth. The 8 p.m. ET kickoff marks Buffalo’s aim to rebound after a 34-25 loss in which Mitch Trubisky topped the Bills’ passing chart, returning to Chicago for joint practices against his former club. Chicago counterpoints with Case Keenum, who produced two touchdowns in their opener as they evaluate backup QB depth ahead of the regular season. The game will also give Mike White and Shane Buechele extended looks for Buffalo behind Josh Allen, testing the back end of the depth chart. Fox broadcast the game locally in Buffalo and Chicago, with NFL+ and Fubo offering streaming options. This matchup isn’t about Week 1 fantasy implications, but it’s a valuable barometer for how teams distribute reps and which players could emerge as sleepers or post-draft adds in deeper leagues.

Trubisky’s return to the Bears puts a spotlight on how Buffalo leverages its clipboard-holdovers and how Chicago prints its depth chart behind Keenum. Buffalo will likely rotate third- and fourth-string reps, while Chicago’s veteran presence could tilt the pace of the game for fantasy managers watching for late-round or dynasty implications. The setting—Soldier Field for a final warmup before regular-season action—adds a narrative edge to a game that will be watched closely by fantasy enthusiasts as a gauge for who might step into meaningful roles in late summer.