James Cook headlines the Bills’ 2025 countdown, with a rope-tight link between 2024 performance and 2025 expectations. In 2024, Cook racked up 1,267 total yards and 18 TDs, including 16 rushing scores, capping a season that earned him a second straight Pro Bowl. Buffalo’s plan for 2025 hinges on Cook shouldering a bulk of the carries, even as Ty Johnson and Ray Davis spell him on third downs. The big question remains: can Buffalo extend Cook amid public contract chatter, and at what price?

Projected to operate at roughly 50% of the snaps in 2024, Cook’s efficiency remained elite, averaging near 5 yards per carry and finding the end zone consistently. If he holds in and lands a reasonable extension, fantasy managers should expect 1,100–1,400 rushing yards with a double-digit TD tally, while the Bills’ offense continues to generate plenty of red-zone opportunities. The contract dynamic could temper volatility, but Cook’s role looks secure for 2025.

Beyond Cook, the countdown highlights a mix of Bills stars and playmakers who’ll shape Buffalo’s ceiling in 2025, including linebackers, defensive linemen, and core pass-catchers who will be counted on to sustain a Lombardi push. The blend of proven veterans and fresh faces under the same offensive system could unlock value across several fantasy rosters as the Bills chase a championship in a loaded AFC.