Week 2 fantasy QB rankings for 2025 spotlight the same mix of elite ceiling and plus-matchup upside that fantasy managers crave. Justin Fields’ rushing floor keeps him in QB1 territory, while Caleb Williams anchors a high-upside Bears offense as a top weekly option in Superflex. Mac Jones enters with a favorable Saints test, and Patrick Mahomes faces a stiff challenge in a rematch against Philadelphia. J.J. McCarthy and Michael Penix Jr. sit as strong Superflex plays, with several veterans and youngsters rounding out the top tiers.

The Week 2 outlook emphasizes risk-reward: injuries and known blockers shift the value of several signal-callers, from Purdy’s out to Mahomes’ matchup dynamics, shaping lineup decisions for fantasy managers who need big weeks from their QBs to carry squads into the weekend.

Buffalo heads to New Jersey hoping to stay undefeated after a historic comeback, facing a Jets club with a revamped offense led by Justin Fields. Buffalo’s plan hinges on clean, quick plays from Josh Allen, a sharper run game, and interior pressure that doesn’t rely on Ed Oliver. Rookie T.J. Sanders steps in as Oliver’s replacement, while DaQuan Jones and the rest of the line must disrupt New York’s rhythm. Watch Dalton Kincaid and the Bills’ big-play receivers against Sauce Gardner and the Jets’ improving defense.

Fantasy managers should monitor Buffalo’s pass-catching corps, the evolving run game, and how Buffalo’s corners fare against Garrett Wilson and a Jets attack eager to prove it can move the ball in the Meadowlands. The game could hinge on Bills’ interior pressure, Benford’s coverage, and Terrel Bernard’s leadership on the second level as Buffalo attempts to move to 2-0 in a tight early AFC East battle.