DeWayne Carter's Achilles tear ends his 2025 season before it begins, leaving Buffalo with interior-line depth questions. Carter appeared in 11 games as a rookie in 2024, delivering 14 tackles with 5 for loss and three QB hits. The Bills now face how to fill those snaps as Carter’s absence amplifies questions about their run defense and interior pressure.

Two DTs on the practice squad, Zion Logue and Jordan Phillips, could be elevated to the 53-man roster to stabilize the rotation. Expect Ed Oliver to shoulder more responsibility up the middle, while depth pieces step into situational roles. Fantasy angles center on how quickly Buffalo can sustain interior disruption against efficient inside runs and quick-hit passes.