Spencer Brown's calf limits Buffalo's Week 4 availability; a cautious approach could keep him sidelined or limited, with Ryan Van Demark ready to start at right tackle if needed.

AJ Epenesa's pec and Ed Oliver's ankle injuries thin Buffalo's edge and interior rush, potentially paving the way for Landon Jackson's NFL debut and moving Dorian Williams into a starting role for Milano. Zion Logue may rotate in at DT, while Keonta Jenkins or Jimmy Ciarlo bolster special teams.

New Orleans may lack a game-changing pass rusher, amplifying the Bills' challenge and shaping fantasy projections around sacks, tackles, and defensive depth on a deep, injury-tinged Bills roster.