Kyler Murray is inactive for Week 6 as the Cardinals face the Colts, with Jacoby Brissett stepping in at quarterback. Arizona shifts to Bam Knight at running back, while Bilal Nichols (personal) and Blake Gillikin (back) are out, and several defenders remain questionable. Brissett's leadership is praised as he embraces a start that tests Arizona’s readiness and game plan execution.

Expect Brissett to lean on a stabilized game plan and a committee-backed rushing approach with Knight, while Zay Jones and the receiving group must prove consistency despite limited practice. The coaching staff emphasizes detail-oriented execution and situational discipline to leverage matches against Indianapolis, shaping the fantasy upside across the Cardinals’ offense this week.