Barrs released from the Cardinals’ practice squad after a brief stint that followed Elijah Simmons’ move to the Buccaneers; Conner out for the season and Collier and Williams on IR, leaving Arizona to manage Week 4 vs Seattle with thin DL and backfield depth.

With only walkthroughs this week, the team may promote from the practice squad or lean on internal depth, shaping the front for a crucial divisional showdown while preserving roster flexibility for the stretch run.

Arizona's cornerback unit is feeling the impact of a wave of injuries. Murphy-Bunting and Starling Thomas were already out, and Williams, Melton, and Will Johnson left Week 2 with injuries. With a Week 3 trip to San Francisco on the horizon and midseason tests vs Green Bay and Dallas looming, the Cardinals are relying on Kei'Trel Clark, Elijah Jones, and Denzel Burke to soak up snaps. Bryce Young’s 328-yard, 3-TD day against Arizona underscored the risk, making the health of the secondary pivotal for fantasy angles.

Kei'Trel Clark has earned upside with increased usage, while Burke’s heavy workload could become a seasonal turning point if Melton and Johnson don’t return soon. This situation creates volatility for Cardinals players and could open opportunities for opponents in upcoming matchups.

Buccaneers sign rookie Elijah Simmons from Arizona's practice squad to the 53-man roster after Calijah Kancey's season-ending injury, adding a traditional two-down run-stopper to TB's interior.

Arizona loses DL depth with L.J. Collier and Garrett Williams landing on IR, exposing thickness issues on the Cardinals' line. Simmons' cross-party move creates immediate TB run-stopping potential while leaving Arizona thinner up front as the season progresses.

Arizona hosts San Francisco in Week 3 with a crowded injury report. Will Johnson DNP groin; Melton limited with a knee; Beachum, Hernandez, Paris Johnson Jr, Reiman, Simon and Stills limited or resting concerns; Jordan James back to full participation with a finger issue. The Cardinals eye a 3-0 start while juggling depth and playmakers.

San Francisco faces a similar test with eight DNPs on the list but Brock Purdy back in limited action as he finishes toe and shoulder rehab. With Nick Bosa resting and Christian McCaffrey dealing with a calf/rest, Kyle Shanahan will lean on creative wrinkles. Kyler Murray notes Levi’s Stadium vibe as a factor in this NFC West clash.