Arizona's Week 5 collapse reshapes the fantasy landscape: Emari Demercado's 72-yard touchdown was wiped out by review, sparking a Titans rally to a 22-21 win. Demercado carried the load in the absence of Conner and Benson, but a costly fumble and a heated sideline moment with coach Jonathan Gannon cast a cloud over Arizona's backfield plan. The Cardinals' defense also faltered late, amplifying uncertainty for fantasy schedulers heading into next week.

Arizona's season hit a rough stretch, slipping to 1-4 after a late loss to Tennessee. Harrison Jr. flashed with 98 receiving yards, but the Cardinals’ WR room remains thin beyond him and Trey McBride. Demercado’s 76-yard TD was wasted by a late fumble, underscoring costly self-inflicted mistakes.

Injuries gutted the backfield—James Conner out for the year and Trey Benson sidelined—deepening depth concerns. With trade chatter heating up around a back like Breece Hall and secondary upgrades needed beyond Will Johnson and Max Melton, the Cardinals may rethink coaching adjustments as they chase cohesion and wins.

Titans aim to rebound in Week 5 against the Arizona Cardinals, led by Cam Ward’s steady, unflinching leadership after a rough 26-0 loss. Arizona’s run game is in flux with James Conner out and Trey Benson on IR, pushing the Cardinals toward a pass-first game plan Tennessee can capitalize on. Arizona’s porous interior line—six sacks allowed last week—opens a favorable path for Jeffery Simmons and Tennessee’s pass rush. This setup creates a meaningful fantasy window for Ward and several Titans playmakers.

The Cardinals’ RB room shakeup and the Titans’ disruptive front create an opportunity for Tennessee to control the tempo early. If Ward and the receiving corps click, Tennessee’s fantasy guys could post usable numbers even in a game that emphasizes defense. Arizona’s offense faces a stern test behind a weakened line, while Tennessee’s defense aims to maintain pressure and stifle a depleted run game, amplifying the upside for key fantasy assets from both teams.