Arizona hosts Tennessee in Week 5 as both teams chase their first win. Card s injuries bite the O-line (Paris Johnson out, interior line rotation), while James Conner is out for the year and Trey Benson sits on IR, forcing a Demercado/Carter/Bam Knight committee. Kyler Murray has managed games under Gannon, with big fourth-quarter drives, but the pass game hasn’t exploded. Arizona plans to lean on Murray and a measured pass to set up the run; Cardinals 27, Titans 13.

Will Hernandez's return from ACL rehab could stabilize Arizona's struggling offensive line just in time for Week 5 against Tennessee. Expected to start at left guard, Hernandez would replace the doubtful Evan Brown and bring leadership and continuity to the interior. His comeback helps Kyler Murray and the run game regain traction as the Cardinals chase a more cohesive, consistent attack.

Cardinals’ Thursday injury report ahead of the Titans game shows Zay Jones and Simi Fehoko clearing concussion protocol, returning to practice, while Darius Robinson remains out with a pectoral. Evan Brown, Greg Dortch, Jon Gaines II, Will Hernandez, and Will Johnson were limited; Kelvin Beachum rested. Bilal Nichols on PUP/neck; Trey Benson on IR (eighth Cardinal eligible to return). Titans’ note: Mike Brown, Blake Hance, JC Latham listed for non-participation with others noted.

Seahawks vs. Cardinals on Thursday Night Football features Seattle getting healthier in the secondary with Julian Love and Devon Witherspoon back, while Josh Jones is out and Anthony Bradford will suit up for added OL depth. Arizona has two offensive linemen inactive. With Seattle’s inactives including Nick Emmanwori and others, the game projects to defense-driven fantasy angles and potential up-front battles, highlighting defensive streams and opportunistic plays on both sides.

Week 4 injury notes reshape cards and Seahawks fantasy outlooks. Zay Jones is out with a concussion for the Cardinals, and Will Johnson is doubtful, thinning the receiving corps as several others are listed as questionable. Arizona also has a handful of solid contributors dealing with minor or rest-related issues. Seattle released Robbie Ouzts to IR, while Anthony Bradford and Zach Charbonnet headline active concerns; multiple defenders and receivers on both sides are in limbo, affecting lineup decisions and DFS targets.