Arizona's season hit a rough stretch, slipping to 1-4 after a late loss to Tennessee. Harrison Jr. flashed with 98 receiving yards, but the Cardinals’ WR room remains thin beyond him and Trey McBride. Demercado’s 76-yard TD was wasted by a late fumble, underscoring costly self-inflicted mistakes.

Injuries gutted the backfield—James Conner out for the year and Trey Benson sidelined—deepening depth concerns. With trade chatter heating up around a back like Breece Hall and secondary upgrades needed beyond Will Johnson and Max Melton, the Cardinals may rethink coaching adjustments as they chase cohesion and wins.

Week 3 injury updates put the San Francisco 49ers in a bind as Brock Purdy's availability for Sunday’s game against Arizona remains highly uncertain. Purdy is limited all week with toe/left shoulder issues and is unlikely to start, elevating the importance of depth at guard and receiver. Connor Colby’s groin and Jauan Jennings’ ankle/shoulder further thin the lineup, while Jordan Watkins’ calf adds another notch to the injury narrative. McCaffrey carries a heavier burden, backed by a rest-conscious defensive plan and a few uncertain blockers. On the other sideline, the Cardinals list a handful of doubtful or limited players up front and in the secondary, setting the stage for a Week 3 test of depth and game plans.