Week 5 carries notable lineup shakes for Titans–Cardinals. Calvin Ridley is listed active for the Titans clash, with Tyjae Spears also active and Kevin Winston Jr. set for his Titans debut. A cluster of Titans blockers and receivers are inactive, thinning the depth chart. For Arizona, Xavier Weaver sits out along with several linemen and defenders, narrowing the Cardinals’ pass-catch and blocking options. Fantasy managers should watch Spears’ workload and Ridley’s involvement for Titans, while assessing Cardinals’ WR depth behind Weaver and the impact of OL/inactive players on their play-calling.

Arizona hosts Tennessee in Week 5 as both teams chase their first win. Card s injuries bite the O-line (Paris Johnson out, interior line rotation), while James Conner is out for the year and Trey Benson sits on IR, forcing a Demercado/Carter/Bam Knight committee. Kyler Murray has managed games under Gannon, with big fourth-quarter drives, but the pass game hasn’t exploded. Arizona plans to lean on Murray and a measured pass to set up the run; Cardinals 27, Titans 13.

Will Hernandez's return from ACL rehab could stabilize Arizona's struggling offensive line just in time for Week 5 against Tennessee. Expected to start at left guard, Hernandez would replace the doubtful Evan Brown and bring leadership and continuity to the interior. His comeback helps Kyler Murray and the run game regain traction as the Cardinals chase a more cohesive, consistent attack.

Cardinals’ Thursday injury report ahead of the Titans game shows Zay Jones and Simi Fehoko clearing concussion protocol, returning to practice, while Darius Robinson remains out with a pectoral. Evan Brown, Greg Dortch, Jon Gaines II, Will Hernandez, and Will Johnson were limited; Kelvin Beachum rested. Bilal Nichols on PUP/neck; Trey Benson on IR (eighth Cardinal eligible to return). Titans’ note: Mike Brown, Blake Hance, JC Latham listed for non-participation with others noted.

Arizona faces Week 5 with backfield uncertainty after Conner and Benson exit, while Beachum returns and Fehoko and Jones clear concussion hurdles, potentially boosting the Arizona offense. Titans list multiple DNPs but get Pollard and Simmons back from rest, shifting defensive and RB depth considerations. Fantasy angles center on Knight/Emari/Mike Carter sharing early Week 5 workload for the Cards, and the Titans leaning on depth along the line and at receiver.