Cardinals’ Thursday injury report ahead of the Titans game shows Zay Jones and Simi Fehoko clearing concussion protocol, returning to practice, while Darius Robinson remains out with a pectoral. Evan Brown, Greg Dortch, Jon Gaines II, Will Hernandez, and Will Johnson were limited; Kelvin Beachum rested. Bilal Nichols on PUP/neck; Trey Benson on IR (eighth Cardinal eligible to return). Titans’ note: Mike Brown, Blake Hance, JC Latham listed for non-participation with others noted.

Arizona faces Week 5 with backfield uncertainty after Conner and Benson exit, while Beachum returns and Fehoko and Jones clear concussion hurdles, potentially boosting the Arizona offense. Titans list multiple DNPs but get Pollard and Simmons back from rest, shifting defensive and RB depth considerations. Fantasy angles center on Knight/Emari/Mike Carter sharing early Week 5 workload for the Cards, and the Titans leaning on depth along the line and at receiver.

Cardinals shift to Trey Benson as the lead early-down back after James Conner’s season-ending injury, with Emari Demercado handling third-down duties. Benson’s workload suggests a buy-low, with several big games ahead as Arizona leans into the passing game and Benson’s burst on early downs. In Seattle, Kenneth Walker III remains the engine of the backfield, while Zach Charbonnet returns and handles more passing-down work; Walker is a solid RB2 with upside if goal-line work stays balanced. Elijah Arroyo’s role grows for Seattle, while Arizona’s pass-game options Dortch, Harrison Jr., and Wilson provide fluctuating fantasy upside. Overall, Cardinals RBs look upgrade-worthy in fantasy, while Seahawks RBs remain a reliable duo with Walker as the steadier floor.

Seahawks vs. Cardinals on Thursday Night Football features Seattle getting healthier in the secondary with Julian Love and Devon Witherspoon back, while Josh Jones is out and Anthony Bradford will suit up for added OL depth. Arizona has two offensive linemen inactive. With Seattle’s inactives including Nick Emmanwori and others, the game projects to defense-driven fantasy angles and potential up-front battles, highlighting defensive streams and opportunistic plays on both sides.

Seahawks and Cardinals clash in a high-upside fantasy spot, led by Jaxon Smith-Njigba’s target-heavy start and Trey McBride’s consistent command of Arizona’s passing game. Smith-Njigba’s 39.7% target share and 55% air yards pair with a cardinal secondary hit by injuries, boosting 80+ receiving yards appeal. McBride sits at a steady seven-plus targets per game, and Seattle’s weakness to tight ends raises 60+ yards upside. With both sides projected to air it out, 1+ passing TD from each side and a brisk pace are in play, making multiple prop avenues attractive and the game total ripe for over-friendly action despite a moderate total.