McMillan steps into Week 2 as Carolina's clear target, delivering a stable WR2 floor despite a modest Week 1. He drew 9 targets, turning them into 68 yards with elite downfield involvement (14.7 aDOT, 47.1% air yards). The matchup with Arizona is decent; Young’s early chemistry with McMillan keeps him in lineups in all formats.

The Week 1 Cardinals game plan allowed over 214 passing yards to Spencer Rattler, paving a path for McMillan to continue earning looks and maintaining volume. Expect Carolina to lean on the rookie as a primary downfield weapon, keeping McMillan firmly in the weekly WR2 mix with modest but real upside if the offense converges on rhythm.

Brock Purdy’s turf-toe injury sidelines the 49ers QB for up to five weeks, thrusting Mac Jones into Sunday’s matchup with New Orleans. Fantasy managers should scan the QB streamer list, with Daniel Jones, Trevor Lawrence, and even Aaron Rodgers cited as viable options in tougher spots.

Week 1’s injury avalanche continued with Austin Ekeler’s season-ending Achilles and George Kittle’s hamstring. Add in Xavier Worthy’s shoulder and Brock Bowers’s knee, and the waiver wire becomes a chessboard. Watch for sleepers like Harold Fannin Jr. and Emeka Egbuka to emerge for deeper leagues.

Arizona elevates Josiah Deguara from the practice squad to serve as a fourth tight end in Week 2 against Carolina, a rare depth move for the Cardinals. With Tip Reiman sidelined and Joey Blount on IR, Deguara’s special-teams prowess and blocking know-how bolster depth while Elijah Higgins and Travis Vokolek absorb more inline duties. Expect the offense to lean on blocking and short-yardage plays, not heavy TE targets in standard leagues.

Carolina did not make roster moves, so Arizona can deploy its four-TE look with familiar pieces. For fantasy managers, monitor how much Deguara contributes on offense beyond special teams, and whether Higgins or Vokolek carve into red-zone opportunities or stay primarily blockers in Week 2.

New Orleans faces a tough test as Spencer Rattler and a battered offense host San Francisco. With Taysom Hill, Foster Moreau, Trevor Penning, and potentially Taliese Fuaga sidelined, the Saints must push a more efficient passing game and smarter play design to avoid an 0-2 start.

For fantasy managers, focus on Rashid Shaheed, Chris Olave, and Alvin Kamara as the trio most likely to produce targets and yards if the Saints unlock play-action and get the ball into space. San Francisco’s defense remains elite up front and in coverage, so protection and precision from Kellen Moore and Rattler will be pivotal for any redemption day in week 2.