Brissett steps in for Murray and threads a season-high 320 yards as the Cardinals push the Colts but slip in a late collapse. The offense flashes a bigger, middle-field throw plan, with Trey McBride soaking up targets and Zay Jones, Greg Dortch, and Elijah Higgins rotating in productive roles. Jonathan Taylor mucks up the Cardinals with a heavy workload, while Arizona’s defense stalls late. At 2-4, the coaching staff faces real scrutiny as the season teeters on the edge.