Seattle’s big-play offense outgunned Arizona 23-20 as the Seahawks piled up 384 yards with 317 coming on 18 plays of 10+ yards. Seattle stitched together two lengthy drives, including a 90-yard march highlighted by three explosive plays, while Jaxon Smith-Njigba and company exploited a thinning Cardinals secondary. Arizona’s defense, thin at corner, yielded chunk gains and two scoring drives, while the offense failed to generate a telltale fourth-quarter takeaway or a decisive late-score surge.

For fantasy managers, Smith-Njigba’s second-half surge and Walker III’s workload on the decisive drives stand out, as does Darnold’s efficiency in the late drive. Arizona’s pass rush showed signs with Campbell and Sweat recording sacks, but the unit again missed opportunities for takeaways. Special teams had its moments, but a late field-goal miss and a conservative burn-the-clock approach kept this one in Seattle’s favor.

Arizona's cornerback unit is feeling the impact of a wave of injuries. Murphy-Bunting and Starling Thomas were already out, and Williams, Melton, and Will Johnson left Week 2 with injuries. With a Week 3 trip to San Francisco on the horizon and midseason tests vs Green Bay and Dallas looming, the Cardinals are relying on Kei'Trel Clark, Elijah Jones, and Denzel Burke to soak up snaps. Bryce Young’s 328-yard, 3-TD day against Arizona underscored the risk, making the health of the secondary pivotal for fantasy angles.

Kei'Trel Clark has earned upside with increased usage, while Burke’s heavy workload could become a seasonal turning point if Melton and Johnson don’t return soon. This situation creates volatility for Cardinals players and could open opportunities for opponents in upcoming matchups.